List of Pharmacology & Toxicology Books

By: Pharma Tips | Views: 17864 | Date: 10-Feb-2013

Top 10 best rated Pharmacology Books 1) Pharmacology: Lippincott's Illustrated Reviews2) USMLE Road Map - Pharmacology3) Katzung's Pharmacology: Examination and Board Review4) Kaplan Lecture Notes: Pharmacology5) Pharmacology Brenner6) Pharmacology: PreTest Self-Assessment and Review7) Elsevier's Integrated Pharmacology8) Lecture Notes on Clinical Pharmacology9) Pharmcards10) Pharmacology - Oklahoma Notes

 

 

Top 10 best rated Pharmacology Books


1) Pharmacology: Lippincott's Illustrated Reviews
2) USMLE Road Map - Pharmacology
3) Katzung's Pharmacology: Examination and Board Review
4) Kaplan Lecture Notes: Pharmacology
5) Pharmacology Brenner
6) Pharmacology: PreTest Self-Assessment and Review
7) Elsevier's Integrated Pharmacology
8) Lecture Notes on Clinical Pharmacology
9) Pharmcards
10) Pharmacology - Oklahoma Notes

 

Rang & Dale's Pharmacology- 7th Edition

 

 


Pharmacology Books


By Humphrey P. Rang, MB MS MA DPhil FMedSci FRS Hon FBPharmacolS, Emeritus Professor of Pharmacology, University College London, London, UK; Maureen M. Dale, MB BCh PhD, Senior Teaching Fellow, Department of Pharmacology, University of Oxford, Oxford, UK; James M. Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King’s College London, London, UK; Rod J. Flower, PhD DSc FBPharmacolS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London, Queen Mary's School of Medicine and Dentistry, London, UK and Graeme Henderson, BSc PhD FBPharmacolS, Professor of Pharmacology, University of Bristol, Bristol, UK
ISBN 9780702034718 · Paperback · 792 Pages · 346 Illustrations
Churchill Livingstone · Published March 2011

Rang & Dale’s Pharmacology provides you with all the knowledge you need to get through your pharmacology course and beyond. Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson present a clear and accessible approach to the analysis of therapeutic agents at the cellular and molecular level through detailed diagrams, full-color illustrations, and pedagogical features. Plus, USMLE-style review questions and additional learning tools online at studentconsult.com make this the perfect resource to turn to for a full understanding of key concepts in pharmacology.


Reviews

"This textbook nimbly covers a wide, complex subject without dumbing it down…It’s easy to read (in bite sized chunks) and the liberal use of colour, and high quality paper, add a feel-good factor". BMA Awards 2007, review of the previous edition


Features
  • Access the fully searchable text online at studentconsult.com, along with 500 USMLE-style multiple-choice review questions, downloadable images, and online only references.

  • Find and cross-reference information quickly using a color-coded layout that makes navigation easy.

  • Effectively understand and review key concepts through detailed diagrams and full-color illustrations that clarify even the most complex concepts.

  • Reinforce your learning with key points boxes and clinical uses boxes that highlight crucial information and clinical applications.


What's New
  • Apply current best practices and clinical applications through thoroughly updated and revised drug information.

  • Stay current with the latest developments in the field thanks to major updates in chapters such as How Drugs Act; Amino Acid Transmitters; Analgesic Drugs; Antidepressant Drugs; and Drug Addiction, Dependence & Abuse.

  • Tap into comprehensive content tailored to your courses with new and reorganized chapters on Host Defense; Inflammatory Mediators; Pharmacogenetics, Pharmacogenomics & Personalized Medicine; Hydroxytoptomine & The Pharmacy of Migraine; and Purines.


Contents

Section 1: General principles



1. What is pharmacology?



2. How drugs act: general principles



3. How drugs act: molecular aspects



4. How drugs act: cellular aspects-excitation, contraction and secretion



5. Cell proliferation, apoptosis, repair and regeneration



6. Cellular mechanisms: host defence



7. Method and measurement in pharmacology



8. Drug absorption and distribution



9. Drug metabolism and elimination



10. Pharmacokinetics



11. Pharmacogenetics, pharmacogenomics and ‘personalised medicine’



Section 2: Chemical mediators



12. Chemical mediators and the autonomic nervous system



13. Cholinergic transmission



14. Noradrenergic transmission



15. 5-Hydroxytryptamine and the pharmacology of migraine



16. Purines



17. Local hormones: cytokines, biologically active lipids, amines andpeptides



18. Cannabinoids



19. Peptides and proteins as mediators



20. Nitric oxide



Section 3: Drugs affecting major organ systems



21. The heart



22. The vascular system



23. Atherosclerosis and lipoprotein metabolism



24. Haemostasis and thrombosis



25. Haemopoietic system and treatment of anaemia



26. Anti-inflammatory and immunosuppressant drugs



27. The respiratory system



28. The kidney



29. The gastrointestinal tract



30. The control of blood glucose and drug treatment of diabetes mellitus



31. Obesity



32. The pituitary and the adrenal cortex



33. The thyroid



34. The reproductive system



35. Bone metabolism



Section 4: The nervous system



36. Chemical transmission and drug action in the central nervous system



37. Amino acid transmitters



38. Other transmitters and modulators



39. Neurodegenerative diseases



40. General anaesthetic agents



41. Analgesic drugs



42. Local anaesthetics and other drugs affecting sodium channels



43. Anxiolytic and hypnotic drugs



44. Antiepileptic drugs



45. Antipsychotic drugs



46. Antidepressant drugs



47. CNS stimulants and psychotomimetic drugs



48. Drug addiction, dependence and abuse



Section 5: Drugs used for the treatment of infections, cancer and immunological disorders



49. Basic principles of antimicrobial chemotherapy



50. Antibacterial drugs



51. Antiviral drugs



52. Antifungal drugs



53. Antiprotozoal drugs



54. Anthelminthic drugs



55. Anticancer drugs



Section 6: Special topics



56. Individual variation and drug interaction



57. Harmful effects of drugs



58. Lifestyle drugs and drugs in sport



59. Biopharmaceuticals and gene therapy



60. Drug discovery and development

 

 List of Pharmacology & Toxicology Books

Bioactive Food Peptides in Health and Disease

Bioactive Food Peptides in Health and Disease

NEW

Editor Blanca Hernandez-Ledesma and Chia-Chien Hsieh

"Bioactive Food Peptides in Health and Disease" highlights recent developments on bioactive food peptides for the promotion of human health and the prevention/management of chronic diseases. The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Aspects related to their bioactivity, mechanism of action, and bioavailability are extensively described along the different chapters. Also, the chapters describe the impact of bioactive peptides on the physiological absorption, regulation and disease prevention. The book also covers the recent technological advances for the production of food peptides. Bioactive Food Peptides in Health and Disease provides updated and interesting information, being a good reference book for nutritional and food scientists, biochemists, industry producers, and consumers.

Chapter 1 
1997-2012: Fifteen Years of Research on Peptide Lunasin
by Blanca Hernández-Ledesma, Ben O. de Lumen and Chia-Chien Hsieh
 Chapter 2 
Bowman-Birk Inhibitors from Legumes: Utilisation in Disease Prevention and Therapy
by Alfonso Clemente, Maria del Carmen Marín-Manzano, Maria del Carmen Arques and Claire Domoney
 Chapter 3 
Antihypertensive Peptides from Food Proteins
by Roseanne Norris and Richard J. FitzGerald
 Chapter 4 
Whey Proteins as Source of Bioactive Peptides Against Hypertension
by Tânia G. Tavares and F. Xavier Malcata
 Chapter 5 
Functional Proteins and Peptides of Hen’s Egg Origin
by Adham M. Abdou, Mujo Kim and Kenji Sato
 Chapter 6 
Antihypertensive Properties of Plant Protein Derived Peptides
by Anne Pihlanto and Sari Mäkinen
 Chapter 7 
Vigna Unguiculata as Source of Angiotensin-I Converting Enzyme Inhibitory and Antioxidant Peptides
by Maira R. Segura-Campos, Luis A. Chel-Guerrero and David A. Betancur-Ancona
 Chapter 8 
Dipeptidyl Peptidase-IV Inhibitory Activity of Peptides in Porcine Skin Gelatin Hydrolysates
by Kuo-Chiang Hsu, Yu-Shan Tung, Shih-Li Huang and Chia-Ling Jao
 Chapter 9 
Snake Venom Peptides: Promising Molecules with Anti-Tumor Effects
by Sameh Sarray, Jose Luis, Mohamed El Ayeb and Naziha Marrakchi
 Chapter 10 
Advancements in the Fractionation of Milk Biopeptides by Means of Membrane Processes
by Claudia Muro, Francisco Riera and Ayoa Fernández
 
Drug Discovery  

Drug Discovery

Editor Hany A. El-Shemy

 

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

 

Chapter 1 
Fruit/Vegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters
by Lourdes Rodríguez-Fragoso and Jorge Reyes-Esparza
 Chapter 2 
Anticancer Drug Discovery — From Serendipity to Rational Design
by Jolanta Natalia Latosińska and Magdalena Latosińska
 Chapter 3 
Drug Interactions, Pharmacogenomics and Cardiovascular Complication
by Irina Piatkov, Trudi Jones and Mark McLean
 Chapter 4 
Interactions with Drugs and Dietary Supplements Used For Weight Loss
by Melanie A. Jordan
 Chapter 5 
Small Molecule Screens to Identify Inhibitors of Infectious Disease
by Elizabeth Hong-Geller and Sofiya Micheva-Viteva
 Chapter 6 
Practical Considerations of Liquid Handling Devices in Drug Discovery
by Sergio C. Chai, Asli N. Goktug, Jimmy Cui, Jonathan Low and Taosheng Chen
 Chapter 7 
Data Analysis Approaches in High Throughput Screening
by Asli N. Goktug, Sergio C. Chai and Taosheng Chen
 Chapter 8 
Oxidative Stress in Human Infectious Diseases – Present and Current Knowledge About Its Druggability
by Carsten Wrenger, Isolmar Schettert and Eva Liebau
 Chapter 9 
Discovery of Selective and Potent Inhibitors of Palmitoylation
by Sonia Lobo Planey
 Chapter 10 
The Antibacterial Drug Discovery
by Jie Yanling, Liang Xin and Li Zhiyuan
 Chapter 11 
Air, Water and Soil: Resources for Drug Discovery
by Luis Jesús Villarreal-Gómez, Irma Esthela Soria-Mercado, Ana Leticia Iglesias and Graciela Lizeth Perez-Gonzalez
 Chapter 12 
Transition State Analogues of Enzymatic Reaction as Potential Drugs
by Karolina Gluza and Pawel Kafarski
 Chapter 13 
Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes
by Charles J. Malemud
 Chapter 14 
Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target
by Louise L. Major, Helen Denton and Terry K. Smith
 Chapter 15 
Colon Cancer: Current Treatments and Preclinical Models for the Discovery and Development of New Therapies
by Samuel Constant, Song Huang, Ludovic Wiszniewski and Christophe Mas
 Chapter 16 
Applications of Snake Venom Proline-Rich Oligopeptides (Bj- PROs) in Disease Conditions Resulting from Deficient Nitric Oxide Production
by Claudiana Lameu and Henning Ulrich
 Chapter 17 
Introduction to Biochemical Pharmacology and Drug Discovery
by Gabriel Magoma

 

New Insights into Toxicity and Drug Testing
New Insights into Toxicity and Drug Testing NEW
Editor Sivakumar Gowder

This book "New Insights into Toxicity and Drug Testing" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.

Chapter 1 
Pre-Clinical Assessment of the Potential Intrinsic Hepatotoxicity of Candidate Drugs
by Jacob John van Tonder, Vanessa Steenkamp and Mary Gulumian
 Chapter 2 
The Kidney Vero-E6 Cell Line: A Suitable Model to Study the Toxicity of Microcystins
by Carina Menezes, Elisabete Valério and Elsa Dias
 Chapter 3 
Why are Early Life Stages of Aquatic Organisms more Sensitive to Toxicants than Adults?
by Azad Mohammed
 Chapter 4 
Screening of Herbal Medicines for Potential Toxicities
by Obidike Ifeoma and Salawu Oluwakanyinsola
 Chapter 5 
New Trends in Genotoxicity Testing of Herbal Medicinal Plants
by Hala M. Abdelmigid
 Chapter 6 
Animal Models in Drug Development
by Ray Greek
 Chapter 7 
Renal Transporters and Biomarkers in Safety Assessment
by P.D. Ward, D. La and J.E. McDuffie
 Chapter 8 
Autophagy: A Possible Defense Mechanism in Parkinson's Disease?
by Rosa A. González-Polo, Rubén Gómez-Sánchez, Lydia Sánchez- Erviti, José M Bravo-San Pedro, Elisa Pizarro-Estrella, Mireia Niso- Santano and José M. Fuentes
 Chapter 9 
Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human
by Micaela B. Reddy, Harvey J. Clewell III, Thierry Lave and Melvin E. Andersen
 Chapter 10 
Plasma Methadone Level Monitoring in Methadone Maintenance Therapy: A Personalised Methadone Therapy
by Nasir Mohamad, Roslanuddin Mohd Salehuddin, Basyirah Ghazali, Nor Hidayah Abu Bakar, Nurfadhlina Musa, Muslih Abdulkarim Ibrahim, Liyana Hazwani Mohd Adnan, Ahmad Rashidi and Rusli Ismail

 

 
Recent Advances in Novel Drug Carrier Systems
Recent Advances in Novel Drug Carrier Systems
Editor Ali Demir Sezer

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

 

Chapter 1 
Hot-Melt Extrusion (HME): From Process to Pharmaceutical Applications
by Mohammed Maniruzzaman, Dennis Douroumis, Joshua S. Boateng and Martin J. Snowden
 Chapter 2 
Development and Investigation of Dry Powder Inhalers for Cystic Fibrosis
by Paola Russo, Antonietta Santoro, Lucia Prota, Mariateresa Stigliani and Rita P. Aquino
 Chapter 3 
The Role of Carrier in Dry Powder Inhaler
by Hamed Hamishehkar, Yahya Rahimpour and Yousef Javadzadeh
 Chapter 4 
Nanotechnology in Drug Delivery
by Martins Ochubiojo Emeje, Ifeoma Chinwude Obidike, Ekaete Ibanga Akpabio and Sabinus Ifianyi Ofoefule
 Chapter 5 
Lipid Nanoparticulate Drug Delivery Systems: A Revolution in Dosage Form Design and Development
by Anthony A. Attama, Mumuni A. Momoh and Philip F. Builders
 Chapter 6 
Niosomes as Carrier in Dermal Drug Delivery
by Yahya Rahimpour and Hamed Hamishehkar
 Chapter 7 
Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery
by Seyda Bucak, Banu Yavuztürk and Ali Demir Sezer
 Chapter 8 
Nanocarrier Systems for Transdermal Drug Delivery
by José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz, Clara Luisa Domínguez-Delgado, Roberto Díaz- Torres, Alma Luisa Revilla-Vázquez, Norma Casas Aléncaster
 Chapter 9 
Targeted Nanoparticles for Cancer Therapy
by M.D. Blanco, C. Teijón, R.M. Olmo and J.M. Teijón
 Chapter 10 
Oral Delivery of Insulin: Novel Approaches
by Amani M. Elsayed
 Chapter 11 
Novel Mucoadhesive Polymers for Nasal Drug Delivery
by Utkarshini Anand, Tiam Feridooni and Remigius U. Agu
 Chapter 12 
Amphiphilic Cyclodextrins, Synthesis, Utilities and Application of Molecular Modeling in Their Design
by Atena Jabbari and Hamid Sadeghian
 Chapter 13 
Processing and Templating of Bioactive-Loaded Polymeric Neural Architectures: Challenges and Innovative Strategies
by Viness Pillay, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit
 Chapter 14 
Novel Drug Delivery Systems for Modulation of Gastrointestinal Transit Time
by Yousef Javadzadeh and Sanaz Hamedeyazdan
 Chapter 15 
Advanced Drug Carriers Targeting Bone Marrow
by Keitaro Sou
 Chapter 16 
Gene Delivery Systems: Recent Progress in Viral and Non-Viral Therapy
by Erdal Cevher, Ali Demir Sezer and Emre Şefik Çağlar
 Chapter 17 
Is Chronic Combination Therapy of HAART and α-ZAM, Herbal Preparation for HIV Infection Safe?
by A. A. Onifade, B.H. Olaseinde and T. Mokowgu
 Chapter 18 
Nanoparticles Toxicity and Their Routes of Exposures
by Ahmet Aydın, Hande Sipahi and Mohammad Charehsaz

 

Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis
Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis
Editor Peter Mikus

The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.

Chapter 1 
Introduction and Overview
by Peter Mikus
 Chapter 2 
Advanced Chiral Separation
by Peter Mikus
 Chapter 3 
Advanced Sample Preparation
by Peter Mikus
 Chapter 4 
Advanced Combinations of Detection and Electrophoresis
by Peter Mikus
 Chapter 5 
Conclusion
by Peter Mikus
 Chapter 6 
Acknowledgements
by Peter Mikus

 

 
Pharmacotherapy
Pharmacotherapy
Editor Farid Badria

The intent of this book is to provide an overview of current conceptualizations of Pharmacotherapy. The book focuses on three major areas; diagnosis, treatment, and prevention for a wide array of diseases; Cognitive and Psychological disorders (Schizophrenia and Nicotine addiction), Inflammatory disorders (New Chemical anti-inflammatory and Immunotherapy), updated antihypertensive therapy and healing of ulcers with venous origin. A separate chapter is dedicated to the rationality of drug use in earthquake injuries. The last chapter deals with Imaging of potential therapeutic or diagnostic agents in animal models in the early stage of research. We hope this book is useful to a wide range of people, from students first learning about Pharmacotherapy, to advanced clinicians and researchers.

 

Chapter 1 
Small Animal Imaging in Development of New Generation Diagnostic and Therapeutic Agents
by Tuulia Huhtala and Ale Närvänen
 Chapter 2 
Rational Drug Use in Medical Response to an Earthquake
by Ling-li Zhang, Yi Liang, Li-nan Zeng and Die Hu
 Chapter 3 
Integration of Pharmacological and Psychosocial Treatment for Schizophrenia in Mexico: The Case of a Developing Country Proposal
by Marcelo Valencia, Alejandro Diaz and Francisco Juarez
 Chapter 4 
Nicotine Addiction: Role of the Nicotinic Acetylcholine Receptors Genetic Variability in Knowledge, Prevention and Treatment
by Candida Nastrucci and Patrizia Russo
 Chapter 5 
Psychiatric Drugs in Medical Practice
by María-José Martín-Vázquez
 Chapter 6 
State of the Art of Anti-Inflammatory Drugs
by Túlio Ricardo Couto de Lima Souza, Graziella Silvestre Marques, Amanda Carla Quintas de Medeiros Vieira and Juliano Carlo Rufino de Freitas
 Chapter 7 
House Dust Mite Immunotherapy in Iraqi Patients with Allergic Rhinitis and Asthma
by Abdulghani Mohamad Alsamarai, Amina Hamed Ahmad Alobaidi, Sami Mezher Alrefaiei and Amar Mohamed Alwan
 Chapter 8 
Efficacy of Aliskiren/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Meta-Analytical Revision
by Manuel Morgado, Sandra Rolo and Miguel Castelo-Branco
 Chapter 9 
LavTIME - A Brand-New Treatment Method of Lasting Wounds - A Multi-Centre Randomized Double-Blind Study on Effectiveness of Polyhexanide and Betaine in Ulcers' Healing with Venous Origin
by Z. Rybak, G Krasowski, R. Wajda and P. Ciesielczyk

 

 

Promising Pharmaceuticals
Promising Pharmaceuticals
Editor Purusotam Basnet

From the dawn of civilization, humans have been dreaming of happy, healthy and long-life. Our life expectancy is twice longer than 100 years ago. We know more about the diseases. Therefore we have developed new drugs to fight against them. The demand for drugs was so high that we developed Pharma industries. Although Pharma industries took responsibility of producing the needed drugs and gave us a quality of life, misuse of drugs brought further complication. Therefore, discovery, production, distribution, and the phase of administration of patients' quality assurance has to be controlled with a technological procedure and tight regulations to make the system as effective as possible for the benefit of human health. Our book provides selected but vital information on the sources, tools, technologies and regulations regarding the current status of medicine development.

 

Chapter 1 
Modern Medicine and Pharmaceutics
by Purusotam Basnet
 Chapter 2 
Drug Designing, Discovery and Development Techniques
by Elvis A. Martis and Rakesh R. Somani
 Chapter 3 
Pharmacognostic Methods for Analysis of Herbal Drugs, According to European Pharmacopoeia
by Duţu Ligia Elena
 Chapter 4 
Biological Products: Manufacturing, Handling, Packaging and Storage
by Nahla S. Barakat
 Chapter 5 
Apparent Solubility and Dissolution Profile at Non-Sink Conditions as Quality Improvement Tools
by Stefania Petralito, Iacopo Zanardi, Adriana Memoli, M. Cristina Annesini, Vincenzo Millucci and Valter Travagli
 Chapter 6 
Good Manufacturing Practices (GMP) for Medicinal Products
by Jaya Bir Karmacharya

 

 

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications
Readings in Advanced Pharmacokinetics - Theory, Methods and Applications
Editor Ayman Noreddin


 This book, "Readings in Advanced Pharmacokinetics - Theory, Methods and Applications", covers up to date information and practical topics related to the study of drug pharmacokinetics in humans and in animals. The book is designed to offer scientists, clinicians and researchers a choice to logically build their knowledge in pharmacokinetics from basic concepts to advanced applications. This book is organized into two sections. The first section discusses advanced theories that include a wide range of topics; from bioequivalence studies, pharmacogenomics in relation to pharmacokinetics, computer based simulation concepts to drug interactions of herbal medicines and veterinary pharmacokinetics. The second section advances theory to practice offering several examples of methods and applications in advanced pharmacokinetics.

Chapter 1 
Bioequivalence Studies
by Aisha Qayyum
 Chapter 2 
Computer Simulations as a Tool for Optimizing Bioequivalence Trials
by Carmen Navarro-Fontestad,Victor Mangas-Sanjuán, Isabel González-Álvarez, Alfredo García-Arieta, Carlos Fernández-Teruel, Vicente G. Casabó-Alós and Marival Bermejo
 Chapter 3 
Evaluation of Percutaneous Drug Permeation Using a Lateral Sectioning Approach
by Nobuhiro Goi, Katsunori Morishita, Akihito Taniguchi and Takayuki Ishii
 Chapter 4 
Pharmacogenomics Dictate Pharmacokinetics: Polymorphisms in Drug-Metabolizing Enzymes and Drug-Transporters
by Debasis Mondal, Samantha L. Gerlach, Amrita Datta, Geetika Chakravarty and Asim B. Abdel-Mageed
 Chapter 5 
Genetic Variation in Drug Disposition
by Balmukunda Regmi and Laxman Bharati
 Chapter 6 
Application of Pharmacokinetics/Pharmacodynamics (PK/PD) in Designing Effective Antibiotic Treatment Regimens
by Ghada F. Ahmed and Ayman M. Noreddin
 Chapter 7 
Pharmacokinetics and Drug Interactions of Herbal Medicines: A Missing Critical Step in the Phytomedicine/Drug Development Process
by Obiageri O. Obodozie
 Chapter 8 
Pharmacokinetics of Antimicrobials in Food Producing Animals
by S. K. Bhavsar and A. M. Thaker
 Chapter 9 
Comparative Veterinary Pharmacokinetics
by Akos Jerzsele
 Chapter 10 
Observer-Based Strategies for Anesthesia Drug Concentration Estimation
by Jin-Oh Hahn, Guy A. Dumont and J. Mark Ansermino
 Chapter 11 
Optimal Pharmacokinetics of Cyclosporine and Tacrolimus Based Relationship Among AUC, Trough and Peak Concentration
by Hironori Takeuchi
 Chapter 12 
Pharmacokinetics and Metabolized Caroteniods in Liver of Single Dose Administration in Fancy Carp (Cyprinus carpio)
by Bundit Yuangsoi
 Chapter 13 
Correlation of in vitro Dissolution Profiles with in vivo Pharmacokinetic Parameters of Some Commercial Brands of Aspirin Tablets Marketed in Nigeria
by Emmanuel Adelaja Bamigbola
 Chapter 14 
Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia
by Malkanthi Evans, Prachi Sharma and Najla Guthrie
 Chapter 15 
Role of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs
by Mohammad-Reza Rashidi and Roghiyeh Pashaei-Asl
 Chapter 16 
Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents
by Daniel Lexcen, Ahmed Salem, Walid M. El-Khatib, Virginia Haynes and Ayman Noreddin
 Chapter 17 
Pharmacokinetic (PK) and Pharmacodynamic Profiles of Artemisinin Derivatives Influence Drug Neurotoxicity in Animals
by Qigui Li and Mark Hickman
 Chapter 18 
One Step Closer to the Target: Intracellular Pharmacokinetics of Gemcitabine
by Matthew Links and Peter Galettis

 

 

Bioterrorism

    Bioterrorism
    Editor Stephen A. Morse
     

This book consists of nine chapters, written by international authorities, discussing various aspects of bioterrorism preparedness and response. Five of the chapters are agent-specific and highlight the pathogenesis, prevention and treatment, and the potential of specific organisms (Rickettsia and Yersinia pestis) or toxins (ricin, botulinum neurotoxins, and staphylococcal enterotoxins) to be used for nefarious purposes. Four chapters discuss different aspects of detecting and responding to a bioterrorism attack. These include methods for spatio-temporal disease surveillance, international laboratory response strategies, detection of botulinum neurotoxins in food and other matrices, and the use of physical methods (ie Raman spectroscopy) to detect spores.

Chapter 1 
Current Methods for Detecting the Presence of Botulinum Neurotoxins in Food and Other Biological Samples
by Luisa W. Cheng, Kirkwood M. Land and Larry H. Stanker
 Chapter 2 
Detection of Bacillus Spores by Surface-Enhanced Raman Spectroscopy
by Stuart Farquharson, Chetan Shende, Alan Gift and Frank Inscore
 Chapter 3 
Staphylococcal Enterotoxins, Staphylococcal Enterotoxin B and Bioterrorism
by Martha L. Hale
 Chapter 4 
Diagnostic Bioterrorism Response Strategies
by Rickard Knutsson
 Chapter 5 
Recent Advancement in the Development of Vaccines Against Y. pestis - A Potential Agent of Bioterrorism
by Riyasat Ali and D.N. Rao
 Chapter 6 
Botulinum Neurotoxins
by Robert P. Webb, Virginia I. Roxas-Duncan and Leonard A. Smith
 Chapter 7 
Ricin Perspective in Bioterrorism
by Virginia I. Roxas-Duncan and Leonard A. Smith
 Chapter 8 
Spatio-Temporal Disease Surveillance
by Ross Sparks, Sarah Bolt and Chris Okugami
 Chapter 9 
Rickettsia and Rickettsial Diseases
by Xue-jie Yu and David H. Walker

Antihypertensive Drugs
Antihypertensive Drugs
Editor Hossein Babaei

Hypertension, known as a "silent killer" is widely prevalent and a major risk factor for cardiovascular diseases. It afflicts more than one billion population worldwide and is a leading cause of morbidity and mortality. The authors of the chapters look from different angles to hypertension, sharing their new knowledge and experience in the direction of deep understanding and more clarification of the disease providing an invaluable resource not only for clinicians, but also for all medical sciences students and health providers.

Chapter 1 
New Therapeutics in Hypertension
by Jorge Luis León Alvarez
 Chapter 2 
Dual L/N-Type Ca2+ Channel Blocker: Cilnidipine as a New Type of Antihypertensive Drug
by Akira Takahara
 Chapter 3 
Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations
by Elsa Morgado and Pedro Leão Neves
 Chapter 4 
Potassium-Sparing Diuretics in Hypertension
by Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi
 Chapter 5 
Hypertension and Renin-Angiotensin System
by Roberto de Barros Silva
 Chapter 6 
Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices
by Yoshihiro Uesawa
 Chapter 7 
Drug Interaction Exposures in an Intensive Care Unit: Population Under Antihypertensive Use
by Érica Freire de Vasconcelos-Pereira, Mônica Cristina Toffoli-Kadri, Leandro dos Santos Maciel Cardinal and Vanessa Terezinha Gubert de Matos
 Chapter 8 
The Use of Antihypertensive Medicines in Primary Health Care Settings
by Marc Twagirumukiza, Jan De Maeseneer, Thierry Christiaens, Robert Vander Stichele and Luc Van Bortel

 

Clinical Use of Local Anesthetics
Clinical Use of Local Anesthetics
Editor Asadolah Saadatniaki

Local anesthetics are being increasingly applied in different surgeries. Lower side effects of neuroaxial anesthesia, regional anesthesia, and field block, in comparison to general anesthesia (volatile and intravenous agents), are the main reasons why physicians prefer to conduct surgeries under local anesthesia, especially in outpatient and day care surgeries. It is important to emphasize the presence of an anesthesiologist, and vigilant monitoring of the homodynamic parameters, in decreasing a patient's anxiety, exerting other modalities for analgesia and increasing the safety margin in many procedures.

Chapter 1 
A New and Enhanced Version of Local Anesthetics in Dentistry
by Tülin Satılmış, Onur Gönül, Hasan Garip and Kamil Göker
 Chapter 2 
Local Anesthesia for Cosmetic Procedures
by Dhepe V. Niteen
 Chapter 3 
Repair of Incisional Hernias of the Midline Under Local Anesthesia in an Ambulatory Basis
by Alberto F. Acevedo
 Chapter 4 
Urological Surgical Procedures Under Local Anesthesia
by M. Hammad Ather, Ammara Mushtaq and M. Nasir Sulaiman
 Chapter 5 
Local Anesthesia for the Prostate Gland
by Allison Glass, Sanoj Punnen and Katsuto Shinohara
 Chapter 6 
Achilles Tendon Repair Under Local Anesthesia
by Andrej Čretnik
 Chapter 7 
The Use of Topical Cream Anesthetics in Office Procedures of the External Genitalia
by Kostis Gyftopoulos

Clinical Applications of Pharmacogenetics
Clinical Applications of Pharmacogenetics
Editor Despina Sanoudou
 
 

The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field.

Chapter 1 
Pharmacogenetics: Matching the Right Foundation at Personalized Medicine in the Right Genomic Era
by Roxana-Georgiana Tauser
 Chapter 2 
Multiplexed Pharmacogenetic Assays for SNP Genotyping: Tools and Techniques for Individualizing Patient Therapy
by Susan J. Hsiao and Alex J. Rai
 Chapter 3 
Role of Pharmacogenetics in Gastrointestinal Cancer
by Suayib Yalcin
 Chapter 4 
Pharmacogenomics of Thiopurine S-Methyltransferase: Clinical Applicability of Genetic Variants
by Sonja Pavlovic, Branka Zukic and Gordana Nikcevic
 Chapter 5 
S-Adenosylmethionine: A Novel Factor in the Individualization of Thiopurine Therapy
by Irena Mlinaric-Rascan, Miha Milek, Alenka Smid and Natasa Karas Kuzelicki
 Chapter 6 
Current Status of Pharmacogenetics in Antithrombotic Drug Therapy
by Eva Gak and Rivka Inzelberg
 Chapter 7 
Clinical Implications of Genetic Admixture in Hispanic Puerto Ricans: Impact on the Pharmacogenetics of CYP2C19 and PON1
by Jorge Duconge, Odalys Escalera, Mohan Korchela and Gualberto Ruaño
 Chapter 8 
Neuropharmacogenetics of Major Depression: Has the Time Come to Take both Sexes into Account?
by Pothitos M. Pitychoutis, Despina Sanoudou, Christina Dalla and Zeta Papadopoulou-Daifoti
 Chapter 9 
Pharmacogenetics of Asthma
by Andrzej Mariusz Fal and Marta Rosiek-Biegus
 Chapter 10 
Pharmacogenomics in Gastroenterology
by Maria Ana Redal, Waldo Horacio Belloso, Paula Scibona, Leonardo Garfi and Santiago Isolabella
 Chapter 11 
The Pharmacogenetics of the Antimalarial Amodiaquine
by José Pedro Gil
 Chapter 12 
Pharmacogenetics and Obstetric Anesthesia and Analgesia
by C. Ortner, C. Ciliberto and R. Landau
 Chapter 13 
Beyond Pharmacogenetics
by Roberto Canaparo


 

Drug Discovery Research in Pharmacognosy

Drug Discovery Research in Pharmacognosy
Editor Omboon Vallisuta and Suleiman M. Olimat

 

This book, Drug Discovery Research in Pharmacognosy provides a full picture of research in the area of pharmacognosy with the goal of drug discovery from natural products based on the traditional knowledge or practices. Several plants that have been used as food show their potential as chemopreventive agents and the claims of many medicinal plants used in traditional medicine are now supported by scientific studies. Drug Discovery Research in Pharmacognosy is a promising road map which will help us find medicine for all!

Chapter 1 
Ayurveda the Ancient Science of Healing: An Insight
by Manoj Goyal, D. Sasmal and B.P. Nagori
 Chapter 2 
Developments in Phytochemistry
by Moronkola Dorcas Olufunke
 Chapter 3 
Analytical Evaluation of Herbal Drugs
by Anjoo Kamboj
 Chapter 4 
Standardized Cannabis and Pain Management
by A. Paul Hornby
 Chapter 5 
The Research of Lygodium
by Zhang Guo-Gang, He Ying-Cui, Liu Hong-Xia, Zhu Lin-Xia and Chen Li-Juan
 Chapter 6 
Natural Alkamides: Pharmacology, Chemistry and Distribution
by María Yolanda Rios
 Chapter 7 
A Comparison Between Lignans from Creosote Bush and Flaxseed and Their Potential to Inhibit Cytochrome P450 Enzyme Activity
by Jennifer Billinsky, Katherine Maloney, Ed Krol and Jane Alcorn
 Chapter 8 
Potential Applications of Euphorbia hirta in Pharmacology
by Mei Fen Shih and Jong Yuh Cherng
 Chapter 9 
Medicinal and Edible Plants as Cancer Preventive Agents
by Ken Yasukawa
 Chapter 10 
Induction and Activation of Plant Secondary Metabolism by External Stimuli
by Fumiya Kurosaki
 Chapter 11 
The Metabolites of Food Microorganisms
by Hirofumi Takigawa and Yusuke Shibuya

 

Epidural Analgesia - Current Views and Approaches
Epidural Analgesia - Current Views and Approaches
Editor Sotonye Fyneface-Ogan

Epidural analgesia is a form of pain relief administered through the space surrounding the dural sheath either by direct injection or via catheter. The agent, when administered, can cause both a loss of sensation (anesthesia) and a loss of pain (analgesia), by reversibly interrupting the transmission of signals through nerves in or near the spinal cord. This form of pain relief has been found useful in many clinical situations. This book intends to provide an in-depth review of the current knowledge on epidural analgesia. The use of this form of analgesia is explored by contributors from different perspectives, including labor and delivery, postoperative analgesia in both pediatric and geriatric patients, and its role during anesthesia and surgery. In order to provide a balanced medical view this book was edited by an obstetric anesthesiologist.

 

Chapter 1 
Anatomy and Clinical Importance of the Epidural Space
by Sotonye Fyneface-Ogan
 Chapter 2 
Local Anaesthetic Epidural Solution for Labour: About Concentrations and Additives
by Christian Dualé and Martine Bonnin
 Chapter 3 
Patient-Controlled Analgesia After Major Abdominal Surgery in the Elderly Patient
by Viorel Gherghina, Gheorghe Nicolae, Iulia Cindea, Razvan Popescu and Catalin Grasa
 Chapter 4 
Epidural Analgesia for Perioperative Upper Abdominal Surgery
by Arunotai Siriussawakul and Aticha Suwanpratheep
 Chapter 5 
The Impact of Epidural Analgesia on Postoperative Outcome After Major Abdominal Surgery
by Iulia Cindea, Alina Balcan, Viorel Gherghina, Bianca Samoila, Dan Costea, Catalin Grasa and Gheorghe Nicolae
 Chapter 6 
Epidural Analgesia in Labour from a Sociological Perspective - A Case Analysis of Andalusia, Spain
by Rafael Serrano-del-Rosal, Lourdes Biedma-Velázquez and José Mª García-de-Diego
 Chapter 7 
Actualities and Perspectives in Continuous Epidural Analgesia During Childbirth in Romania
by Virgil Dorca, Dan Mihu, Diana Feier, Adela Golea and Simona Manole
 Chapter 8 
Combined Spinal Epidural Anesthesia and Analgesia
by Dusica Stamenkovic and Menelaos Karanikolas
 Chapter 9 
Contraindications - Hemorrhage and Coagulopathy, and Patient Refusal
by Bahanur Cekic and Ahmet Besir

Antiviral Drugs - Aspects of Clinical Use and Recent Advances
Antiviral Drugs - Aspects of Clinical Use and Recent Advances
Editor Patrick Arbuthnot

The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies.

 

Chapter 1 
Antiviral Therapy in HCV-Infected Decompensated Cirrhotics
by Fazal-I-Akbar Danish
 Chapter 2 
Virus Diagnostics and Antiviral Therapy in Acute Retinal Necrosis (ARN)
by Peter Rautenberg, Jost Hillenkamp, Livia Grančičova, Bernhard Nölle, Johann Roider and Helmut Fickenscher
 Chapter 3 
Leflunomide an Immunosuppressive Drug for Antiviral Purpose in Treatment for BK Virus-Associated Nephropathy After Kidney Transplantation
by Christophe Bazin
 Chapter 4 
Modeling Virologic Response in HIV-1 Infected Patients to Assess Medication Adherence
by Yangxin Huang
 Chapter 5 
Use of Animal Models for Anti-HIV Drug Development
by Zandrea Ambrose
 Chapter 6 
Discovery of Novel Antiviral Agents Directed Against the Influenza A Virus Nucleoprotein
by Yoko Aida, Yutaka Sasaki and Kyoji Hagiwara
 Chapter 7 
Targeting Norovirus: Strategies for the Discovery of New Antiviral Drugs
by Joana Rocha-Pereira and Maria São José Nascimento
 Chapter 8 
Single Domain Camelid Antibodies that Neutralize Negative Strand Viruses
by Francisco Miguel Lopez Cardoso, Lorena Itatí Ibañez, Bert Schepens and Xavier Saelens
 Chapter 9 
Treatment of Herpes Simplex Virus with Lignin-Carbohydrate Complex Tablet, an Alternative Therapeutic Formula
by Blanca Silvia González López, Masaji Yamamoto and Hiroshi Sakagami

 

Virtual Screening
Virtual Screening
Editor Mutasem O. Taha

Pharmacophore modeling, QSAR analysis, CoMFA, CoMSIA, docking and molecular dynamics simulations, are currently implemented to varying degrees in virtual screening towards discovery of new bioactive hits. Implementation of such techniques requires multidisciplinary knowledge and experience. This volume discusses established methodologies as well as new trends in virtual screening with aim of facilitating their use in drug discovery.

Chapter 1 
Mixing Pharmacophore Modeling and Classical QSAR Analysis as Powerful Tool for Lead Discovery
by Mutasem O. Taha
 Chapter 2 
Recent Advances and Future Trend on the Emerging Role of GPUs as Platforms for Virtual Screening-Based Drug Discovery
by Horacio Pérez-Sánchez, José M. Cecilia and José M. García
 Chapter 3 
CoMFA/CoMSIA and Pharmacophore Modelling as a Powerful Tools for Efficient Virtual Screening: Application to Anti-Leishmanial Betulin Derivatives
by Leo Ghemtio, Yuezhou Zhang and Henri Xhaard
 Chapter 4 
Virtual Screening of Acetylcholinesterase Inhibitors
by Chen Dan, Pan Ya-fei, Li Chuan-jun, Xie Yun-feng and Jiang Yu-ren
 Chapter 5 
Computational Virtual Screening Towards Designing Novel Anticancer Drugs
by Po-Yuan Chen
 

Pharmacology
Pharmacology
Editor Luca Gallelli

The history of pharmacology travels together to history of scientific method and the latest frontiers of pharmacology open a new world in the search of drugs. New technologies and continuing progress in the field of pharmacology has also changed radically the way of designing a new drug. In fact, modern drug discovery is based on deep knowledge of the disease and of both cellular and molecular mechanisms involved in its development. The purpose of this book was to give a new idea from the beginning of the pharmacology, starting from pharmacodynamic and reaching the new field of pharmacogenetic and ethnopharmacology.

 

Chapter 1 
Metabotropic Receptors for Glutamate and GABA
by Gregory Stewart, Julie Kniazeff, Laurent Prézeau, Philippe Rondard, Jean-Philippe Pin and Cyril Goudet
 Chapter 2 
Interactions Between Glutamate Receptors and TRPV1 Involved in Nociceptive Processing at Peripheral Endings of Primary Afferent Fibers
by You-Hong Jin, Motohide Takemura, Akira Furuyama and Norifumi Yonehara
 Chapter 3 
Molecular Pharmacology of Nucleoside and Nucleotide HIV-1 Reverse Transcriptase Inhibitors
by Brian D. Herman and Nicolas Sluis-Cremer
 Chapter 4 
Opioid Kappa Receptor Selective Agonist TRK-820 (Nalfurafine Hydrochloride)
by Hideaki Fujii, Shigeto Hirayama and Hiroshi Nagase
 Chapter 5 
The Cannabinoid 1 Receptor and Progenitor Cells in the Adult Central Nervous System
by Alexandra Sideris, Thomas Blanck and Esperanza Recio-Pinto
 Chapter 6 
Peroxisome Proliferator Activated Receptor Alpha (PPAR) Agonists: A Potential Tool for a Healthy Aging Brain
by Jennifer Tremblay-Mercier
 Chapter 7 
The Influence of Cyclophosphamide on Immune Function of Murine Macrophages
by Krzysztof Bryniarski
 Chapter 8 
Modification of Interleukin-10 with Mannose-6-Phosphate Groups Yields a Liver-Specific Cytokine with Antifibrotic Activity in Rats
by Heni Rachmawati, Adriana Mattos, Catharina Reker-Smit, Klaas Poelstra and Leonie Beljaars
 Chapter 9 
Pharmacogenetics: The Scientific Basis
by Bosun Banjoko
 Chapter 10 
Future of Pharmacogenetics in Cardiovascular Diseases
by Rianne M.F. Van Schie, Talitha I. Verhoef, Anke-Hilse Maitland-Van Der Zee, Anthonius de Boer, Tom Schalekamp, Felix J.M. Van Der Meer, William K. Redekop and Rahber Thariani
 Chapter 11 
Warfarin Enantiomers Pharmacokinetics by CYP2C19
by Yumiko Akamine and Tsukasa Uno
 Chapter 12 
Pharmacogenetics - A Treatment Strategy for Alcoholism
by Anjana Munshi and Vandana Sharma
 Chapter 13 
Pharmacological Approaches to Improve Ageing
by Pedro J. Camello, Cristina Camello-Almaraz and Maria J. Pozo
 Chapter 14 
Pharmacological Neuromodulation in Autism Spectrum Disorders
by Bill J. Duke
 Chapter 15 
Pharmacology of Hormone Replacement Therapy in Menopause
by Adela Voican, Bruno Francou, Liliana Novac, Nathalie Chabbert-Buffet, Marianne Canonico, Geri Meduri, Marc Lombes, Pierre-Yves Scarabin, Jacques Young, Anne Guiochon-Mantel and Jérôme Bouligand
 Chapter 16 
A Multi-Level Analysis of World Scientific Output in Pharmacology
by Carlos Olmeda-Gómez, Ma-Antonia Ovalle-Perandones and Antonio Perianes-Rodríguez
 Chapter 17 
Mephedrone-Related Fatalities in the United Kingdom: Contextual, Clinical and Practical Issues
by John M. Corkery, Fabrizio Schifano and A. Hamid Ghodse
 Chapter 18 
Novel Strategies in Drug-Induced Acute Kidney Injury
by Alberto Lázaro, Sonia Camaño, Blanca Humanes and Alberto Tejedor
 Chapter 19 
Chemical and Physical Enhancers for Transdermal Drug Delivery
by José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz and Clara Luisa Domínguez-Delgado
 Chapter 20 
Application of Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry
by Nobuhiro Zaima
 Chapter 21 
Closed-Loop Control of Anaesthetic Effect
by Santiago Torres, Juan A. Méndez, Héctor Reboso, José A. Reboso and Ana León
 Chapter 22 
The Influence of Displacement by Human Groups Among Regions in the Medicinal Use of Natural Resource: A Case Study in Diadema, São Paulo - Brazil
by Daniel Garcia and Lin Chau Ming
 Chapter 23 
Unconventional Raw Natural Sustainable Sources for Obtaining Pharmacological Principles Potentially Active on CNS Through Catalytic, Ecologically Clean, Processes
by Yanier Nuñez Figueredo, Juan E. Tacoronte Morales, Alicia Lagarto Parra, Olinka Tiomno Tiomnova, Jorge Tobella Sabater and Jorge Leyva Simeon
 Chapter 24 
Elucidating the Role of Biliverdin Reductase in the Expression of Heme Oxygenase-1 as a Cytoprotective Response to Stress
by James R. Reed
 Chapter 25 
Antibothropic Action of Camellia sinensis Extract Against the Neuromuscular Blockade by Bothrops jararacussu Snake Venom and Its Main Toxin, Bothropstoxin-I
by Yoko Oshima-Franco, Luana de Jesus Reis Rosa, Gleidy Ana Araujo Silva, Jorge Amaral Filho, Magali Glauzer Silva, Patricia Santos Lopes, José Carlos Cogo, Adélia Cristina Oliveira Cintra and Maria Alice da Cruz-Höfling
 Chapter 26 
The Effects of Viscum album (Mistletoe) QuFrF Extract and Vincristine in Human Multiple Myeloma Cell Lines - A Comparative Experimental Study Using Several and Different Parameters
by Eva Kovacs
 Chapter 27 
Ethanol Toxicity in the Brain: Alteration of Astroglial Cell Function
by Metoda Lipnik-Štangelj
 Chapter 28 
The Involvement of Purinergic System in Pain: Adenosine Receptors and Inosine as Pharmacological Tools in Future Treatments
by Francisney Pinto Nascimento, Sérgio José Macedo Jr. and Adair Roberto Soares Santos
 Chapter 29 
Therapeutic Organometallic Compounds
by Beril Anilanmert
 Chapter 30 
Aging: Drugs to Eliminate Methylglyoxal, a Reactive Glucose Metabolite, and Advanced Glycation Endproducts
by Indu Dhar and Kaushik Desai
 Chapter 31 
Ethanol Interference on Adenosine System
by Silvânia Vasconcelos, Sarah Escudeiro, Ana Luíza Martin, Paula Soares, Antônio Vieira Filho, Larissa Silva, Kátia Cilene Dias, Danielle Macêdo, Francisca Cléa Sousa and Marta Fonteles

Chemical Kinetics
Chemical Kinetics
Editor Vivek Patel

Chemical Kinetics relates to the rates of chemical reactions and factors such as concentration and temperature, which affects the rates of chemical reactions. Such studies are important in providing essential evidence as to the mechanisms of chemical processes. The book is designed to help the reader, particularly students and researchers of physical science, understand the chemical kinetics mechanics and chemical reactions. The selection of topics addressed and the examples, tables and graphs used to illustrate them are governed, to a large extent, by the fact that this book is aimed primarily at physical science (mainly chemistry) technologists. Undoubtedly, this book contains "must read" materials for students, engineers, and researchers working in the chemistry and chemical kinetics area. This book provides valuable insight into the mechanisms and chemical reactions. It is written in concise, self-explanatory and informative manner by a world class scientists in the field.

 

Chapter 1 
Chemical Kinetics, an Historical Introduction
by Stefano Zambelli
 Chapter 2 
On the Interrelations Between Kinetics and Thermodynamics as the Theories of Trajectories and States
by Boris M. Kaganovich, Alexandre V. Keiko, Vitaly A. Shamansky and Maxim S. Zarodnyuk
 Chapter 3 
Chemical Kinetics and Inverse Modelling Problems
by Victor Martinez-Luaces
 Chapter 4 
Model Reduction Techniques for Chemical Mechanisms
by Terese Løvås
 Chapter 5 
Vibrational and Chemical Kinetics in Non-Equilibrium Gas Flows
by E. V. Kustova and E. A. Nagnibeda
 Chapter 6 
Numerical Analysis of the Effect of Inhomogeneous Pre-Mixture on Pressure Rise Rate in HCCI Engine by Using Multi-Zone Chemical Kinetics
by Ock Taeck Lim and Norimasa Iida
 Chapter 7 
Ignition Process in a Non-Homogeneous Mixture
by Hiroshi Kawanabe
 Chapter 8 
Chemical Kinetics in Cold Plasmas
by Ruggero Barni and Claudia Riccardi
 Chapter 9 
Chemical Kinetics in Air Plasmas at Atmospheric Pressure
by Claudia Riccardi and Ruggero Barni
 Chapter 10 
The Chemical Kinetics of Shape Determination in Plants
by David M. Holloway
 Chapter 11 
Plasma-Chemical Kinetics of Film Deposition in Argon-Methane and Argon-Acetylene Mixtures Under Atmospheric Pressure Conditions
by Ramasamy Pothiraja, Nikita Bibinov and Peter Awakowicz
 Chapter 12 
Recent Developments on the Mechanism and Kinetics of Esterification Reaction Promoted by Various Catalysts
by Zuoxiang Zeng, Li Cui, Weilan Xue, Jing Chen and Yu Che
 Chapter 13 
Progresses in Experimental Study of N2 Plasma Diagnostics by Optical Emission Spectroscopy
by Hiroshi Akatsuka
 Chapter 14 
Nanoscale Liquid is Second Liquid
by Boris A. Mosienko
 Chapter 15 
Application of Catalysts to Metal Microreactor Systems
by Pfeifer Peter

Topics on Drug Metabolism
Topics on Drug Metabolism
Editor James Paxton

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

 

Chapter 1 
Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability
by Ayman El-Kattan and Manthena Varma
 Chapter 2 
Phase II Drug Metabolism
by Petra Jančová and Michal Šiller
 Chapter 3 
Pharmacogenetics and Metabolism: Past, Present and Future
by Fabricio Rios-Santos and Luiz Alexandre V. Magno
 Chapter 4 
Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance
by Viola Tamási and András Falus
 Chapter 5 
Altered Drug Metabolism and Transport in Pathophysiological Conditions
by Adarsh Gandhi and Romi Ghose
 Chapter 6 
Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches
by Hanane Akhdar, Claire Legendre, Caroline Aninat and Fabrice More
 Chapter 7 
Transcription Factors Potentially Involved in Regulation of Cytochrome P450 Gene Expression
by Piotr Czekaj and Rafał Skowronek
 Chapter 8 
Determination of Cytochrome P450 Metabolic Activity Using Selective Markers
by Jan Jurica and Alexandra Sulcova
 Chapter 9 
Electrochemical Methods for the In Vitro Assessment of Drug Metabolism
by Alejandro Álvarez-Lueje, Magdalena Pérez and Claudio Zapata
 Chapter 10 
Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism Using Liquid Chromatography-Tandem Mass Spectrometry Technology
by Jinsong Ni and Josh Rowe
 Chapter 11 
Label-Free Quantitative Analysis Using LC/MS
by Atsumu Hirabayashi
 Chapter 12 
Recent Advances in Pharmacogenomic Technology for Personalized Medicine
by Toshihisa Ishikawa and Yoshihide Hayashizaki

Chemical Biology
Chemical Biology
Editor Deniz Ekinci

Chemical biology utilizes chemical principles to modulate systems to either investigate the underlying biology or create new function. Over recent years, chemical biology has received particular attention of many scientists in the life sciences from botany to medicine. This book contains an overview focusing on the research area of protein purification, enzymology, vitamins, antioxidants, biotransformation, gene delivery, signaling, regulation and organization. Particular emphasis is devoted to both theoretical and experimental aspects. The textbook is written by international scientists with expertise in synthetic chemistry, protein biochemistry, enzymology, molecular biology, drug discovery and genetics many of which are active chemical, biochemical and biomedical research. The textbook is expected to enhance the knowledge of scientists in the complexities of chemical and biological approaches and stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of chemical biology.

 

Chapter 1 
Protein Purification
by Nison Sattayasai
 Chapter 2 
The Problems Associated with Enzyme Purification
by Etienne Dako, Anne-Marie Bernier, Adjéhi Thomas Dadie and Christopher K. Jankowski
 Chapter 3 
Nicotinamide Phosphoribosyltransferase Inhibitors
by Dan Wu, Dilyara Cheranova, Daniel P. Heruth, Li Qin Zhang and Shui Qing Ye
 Chapter 4 
Cofactor Recycling Using a Thermostable NADH Oxidase
by Jun-ichiro Hirano, Hiromichi Ohta, Shosuke Yoshida and Kenji Miyamoto
 Chapter 5 
Analyses of Sequences of (β/α) Barrel Proteins Based on the Inter-Residue Average Distance Statistics to Elucidate Folding Processes
by Masanari Matsuoka, Michirou Kabata, Yosuke Kawai and Takeshi Kikuchi
 Chapter 6 
Functional Implication Guided by Structure-Based Study on Catalase – Peroxidase (KatG) from Haloarcula Marismortui
by Takao Sato
 Chapter 7 
Effects of Dietary Fortification of Vitamin A and Folic Acid on the Composition of Chicken Egg
by M.J. Ogundare and S.A. Bolu
 Chapter 8 
Mitochondria and Antioxidants: The Active Players in Islet Oxidative Stress
by Tatyana V. Votyakova, Rita Bottino and Massimo Trucco
 Chapter 9 
Nitric Oxide Signaling During Senescence and Programmed Cell Death in Leaves
by Meena Misra, Amarendra Narayan Misra and Ranjeet Singh
 Chapter 10 
Menaquinone as Well as Ubiquinone as a Crucial Component in the Escherichia coli Respiratory Chain
by Naoko Fujimoto, Tomoyuki Kosaka and Mamoru Yamada
 Chapter 11 
Genetically Modified Baker’s Yeast Saccharomyces cerevisiae in Chemical Synthesis and Biotransformations
by Ewa Białecka-Florjańczyk and Agata Urszula Kapturowska
 Chapter 12 
Animal Models for Hydrodynamic Gene Delivery
by Michalis Katsimpoulas, Dimitris Zacharoulis, Nagy Habib and Alkiviadis Kostakis
 Chapter 13 
Role of β-Arrestins in Endosomal Sorting of G Protein-Coupled Receptors
by Rohit Malik and Adriano Marchese
 Chapter 14 
Structure and Function of the Lipolysis Stimulated Lipoprotein Receptor
by Christophe Stenger, Catherine Corbier and Frances T. Yen
 Chapter 15 
Ghrelin, a Gastric Hormone with Diverse Functions
by Ziru Li, Jie Luo, Yin Li and Weizhen Zhang
 Chapter 16 
Polysialylation of the Neural Cell Adhesion Molecule: Setting the Stage for Plasticity Across Scales of Biological Organization
by Marie-Claude Amoureux, Annelise Viallat, Coralie Giribone, Marion Benezech, Philippe Marino, Gaelle Millet, Isabelle Boquet, Jean-Chrétien Norreel and Geneviève Rougon
 Chapter 17 
What Does Maurocalcine Tell Us About the Process of Excitation-Contraction Coupling?
by Michel Ronjat and Michel De Waard
 Chapter 18 
13C-Metabolic Flux Analysis and Metabolic Regulation
by Yu Matsuoka and Kazuyuki Shimizu
 Chapter 19 
QCM as Cell-Based Biosensor
by Tsong-Rong Yan, Chao-Fa Lee and Hung-Che Chou

Ecotoxicology
Ecotoxicology
Editor Ghousia Begum

This is a good book on upcoming areas of Ecotoxicology. The first chapter describes genotoxicity of heavy metals in plants. The second chapter offer views on chromatographic methodologies for the estimation of mycotoxin. Chapter three is on effects of xenobiotics on benthic assemblages in different habitats of Australia. Laboratory findings of genotoxins on small mammals are presented in chapter four. The fifth chapter describes bioindicators of soil quality and assessment of pesticides used in chemical seed treatments. European regulation REACH in marine ecotoxicology is described in chapter six. X-ray spectroscopic analysis for trace metal in invertebrates is presented in chapter seven. The last chapter is on alternative animal model for toxicity testing. In conclusion, this book is an excellent and well organized collection of up dated information on Ecotoxicology. The data presented in it might be a good starting point to develop research in the field of ECOTOXICOLOGY.

 

Chapter 1 
Contribution of X-Ray Spectroscopy to Marine Ecotoxicology: Trace Metal Bioaccumulation and Detoxification in Marine Invertebrates
by Sabria Barka
 Chapter 2 
Soil Ecotoxicology
by Elke Jurandy Bran Nogueira Cardoso and Paulo Roger Lopes Alves
 Chapter 3 
Alternative Biotest on Artemia franciscana
by Petr Dvorak, Katarina Benova and Jiri Vitek
 Chapter 4 
Patulin Analysis: Sample Preparation Methodologies and Chromatographic Approaches
by Sara Pires, João Lopes, Inês Nunes and Elvira Gaspar
 Chapter 5 
Utilization of Marine Crustaceans as Study Models: A New Approach in Marine Ecotoxicology for European (REACH) Regulation
by Pane Luigi, Agrone Chiara, Giacco Elisabetta, Somà Alessandra and Mariottini Gian Luigi
 Chapter 6 
Comparative Genotoxicity Analysis of Heavy Metal Contamination in Higher Plants
by Sumer Aras, Semra Soydam Aydin, Didem Aksoy Körpe and Çiğdem Dönmez
 Chapter 7 
Genomic Sensitivity of Small Mammals - A Suitable Test System in the Genetic Monitoring
by Margarita Topashka-Ancheva and Tsvetelina Gerasimova

Bioactive Compounds in Phytomedicine
Bioactive Compounds in Phytomedicine
Editor Iraj Rasooli

There are significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Herbal therapy is less expensive, more readily available, and increasingly becoming common practice all over the world. Such practices have both their benefits and risks. However, herbal self-therapy might have serious health consequences due to incorrect self-diagnosis, inappropriate choice of herbal remedy or adulterated herbal product. In addition, absence of clinical trials and other traditional safety mechanisms before medicines are introduced to the wider market results in questionable safe dosage ranges which may produce adverse and unexpected outcomes. Therefore, the use of herbal remedies requires sufficient knowledge about the efficacy, safety and proper use of such products. Hence, it is necessary to have baseline data regarding the use of herbal remedies and to educate future health professionals about various aspects of herbal remedies.

 

Chapter 1 
Selecting Medicinal Plants for Development of Phytomedicine and Use in Primary Health Care
by Wagner Luiz Ramos Barbosa, Myrth Soares do Nascimento, Lucianna do Nascimento Pinto, Fernando Luiz Costa Maia, Antonio Jorge Ataíde Sousa, José Otávio Carréra Silva Júnior, Maurícia Melo Monteiro and Danilo Ribeiro de Oliveira
 Chapter 2 
Hepatoprotective Effect of Zanthoxylum armatum DC
by Nitin Verma and Rattan Lal Khosa
 Chapter 3 
Current Status: Mexican Medicinal Plants with Insecticidal Potential
by Ludmila Elisa Guzmán-Pantoja, Laura P. Lina-García, Graciela Bustos-Zagal and Víctor M. Hernández-Velázquez
 Chapter 4 
Standardization of Herbal Drugs Derivatives with Special Reference to Brazilian Regulations
by Wagner Luiz Ramos Barbosa, Lucianna do Nascimento Pinto, Luiz Cláudio Silva Malheiros, Patricia Miriam Sayuri Sato Barros, Christian Barbosa de Freitas, Jose Otavio Carrera Silva Junior, Sandra Gallori and Franco Francesco Vincieri
 Chapter 5 
The Phytochemical and In Vitro Pharmacological Testing of Maltese Medicinal Plants
by Everaldo Attard and Pierpaolo Pacioni
 Chapter 6 
Phytochemicals Components as Bioactive Foods
by Aicha Olfa Cherif
 Chapter 7 
Diosgenin, a Steroid Saponin Constituent of Yams and Fenugreek: Emerging Evidence for Applications in Medicine
by Jayadev Raju and Chinthalapally V. Rao
 Chapter 8 
Polyphenols as Adaptogens – The Real Mechanism of the Antioxidant Effect?
by David E. Stevenson
 Chapter 9 
Erythrina, a Potential Source of Chemicals from the Neotropics
by R. Marcos Soto-Hernández, Rosario García-Mateos, Rubén San Miguel-Chávez, Geoffrey Kite, Mariano Martínez-Vázquez and Ana C. Ramos-Valdivia
 Chapter 10 
Zanthoxylum Genus as Potential Source of Bioactive Compounds
by L. Oscar Javier Patiño, R. Juliet Angélica Prieto and S. Luis Enrique Cuca

Pain Management - Current Issues and Opinions
Pain Management - Current Issues and Opinions
Editor Gabor B. Racz and Carl E. Noe

Pain Management - Current Issues and Opinions is written by international experts who cover a number of topics about current pain management problems, and gives the reader a glimpse into the future of pain treatment. Several chapters report original research, while others summarize clinical information with specific treatment options. The international mix of authors reflects the "casting of a broad net" to recruit authors on the cutting edge of their area of interest. Pain Management - Current Issues and Opinions is a must read for the up-to-date pain clinician.

 

Chapter 1 
Intrathecal Studies on Animal Pain Models
by Jen-Kun Cheng
 Chapter 2 
Polymer Based Therapies for the Treatment of Chronic Pain
by Pradeep K. Dhal, Diego A. Gianolio and Robert J. Miller
 Chapter 3 
Molecular Aspects of Opioid Receptors and Opioid Receptor Painkillers
by Austin B. Yongye and Karina Martínez-Mayorga
 Chapter 4 
Creation of New Local Anesthetics Based on Quinoline Derivatives and Related Heterocycles
by Igor Ukrainets
 Chapter 5 
Neuroprotection and Pain Management
by Kambiz Hassanzadeh and Esmael Izadpanah
 Chapter 6 
Reduced Antinociceptive Effect of Repeated Treatment with a Cannabinoid Receptor Type 2 Agonist in Cannabinoid-Tolerant Rats Following Spinal Nerve Transection
by Matthew S. Alkaitis, Christian Ndong, Russell P. Landry III, Joyce A. DeLeo and E. Alfonso Romero-Sandoval
 Chapter 7 
Applied Radiologic Science in the Treatment of Pain: Interventional Pain Medicine
by Kevin L. Wininger
 Chapter 8 
Local Anesthetic Agents in Arthroscopy
by Joseph Baker
 Chapter 9 
Multimodal Analgesia for Postoperative Pain Management
by G. Ulufer Sivrikaya
 Chapter 10 
The Effect of General Anesthesia and General Anesthesia Plus Epidural Levobupivacaine or Bupivacaine on Hemodynami Stress Response and Postoperative Pain
by Semra Calimli, Ahmet Topal, Atilla Erol, Aybars Tavlan and Seref Otelcioglu
 Chapter 11 
Propofol and Postoperative Pain: Systematic Review and Meta-Analysis
by Antigona Hasani, Hysni Jashari, Valbon Gashi and Albion Dervishi
 Chapter 12 
Efficacy of Continuous Femoral Nerve Block with Stimulating Catheters Versus Nonstimulating Catheters - A Systematic-Narrative Review
by Mario Dauri, Ludovica Celidonio, Sarit Nahmias, Eleonora Fabbi, Filadelfo Coniglione and Maria Beatrice Silvi
 Chapter 13 
Regional Anesthesia for the Trauma Patient
by Stephen D. Lucas, Linda Le-Wendling and F. Kayser Enneking
 Chapter 14 
Opioid Analgesics
by Maree T. Smith and Wei H. Goh
 Chapter 15 
Pain Management and Costs of a Combination of Oxycodone + Naloxone in Low Back Pain Patients
by R. Rychlik, K. Viehmann, D. Daniel, P. Kiencke and J. Kresimon
 Chapter 16 
The Role of Opioid Analgesics in the Treatment of Pain in Cancer Patients
by Wojciech Leppert
 Chapter 17 
Epidural Lysis of Adhesions and Percutaneous Neuroplasty
by Gabor B. Racz, Miles R. Day, James E. Heavner, Jeffrey P. Smith, Jared Scott, Carl E. Noe, Laslo Nagy and Hana Ilner
 Chapter 18 
Chronic Pain in People with Physically Disabling Conditions: A Review of the Application of Biopsychosocial Models
by Kathryn Nicholson Perry
 Chapter 19 
The Role of Peripheral Nerve Blocks in the Interdisciplinary Care of Children with Chronic Pain: A Case Series and Review of the Literature
by Gillian R. Lauder and Nicholas West
 Chapter 20 
Risk Factors in Opioid Treatment of Chronic Non-Cancer Pain: A Multidisciplinary Assessment
by Renata Ferrari, Michela Capraro and Marco Visentin
 Chapter 21 
Psychological Strategies in Pain Management: Optimizing Procedures in Clinics
by FuZhou Wang
 Chapter 22 
Radiation Mucositis
by P. S. Satheesh Kumar
 Chapter 23 
Non-Pharmacological Therapies in Pain Management
by Yurdanur Demir
 Chapter 24 
Overview of Collateral Meridian Therapy in Pain Management: A Modified Formulated Chinese Acupuncture
by Chih-Shung Wong, Chun-Chang Yeh and Shan-Chi Ko
 Chapter 25 
When Theoretical Knowledge Is Not Enough: Introduction of an Explanatory Model on Nurse’s Pain Management
by Katrin Blondal and Sigridur Halldorsdottir
 Chapter 26 
Complex Regional Pain Syndrome
by Gabor B. Racz and Carl E. Noe

Drug Discovery and Development - Present and Future
Drug Discovery and Development - Present and Future
Editor Izet M. Kapetanovic

Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

 

Chapter 1 
Drug Discovery and Ayurveda: Win-Win Relationship Between Contemporary and Ancient Sciences
by Bhushan Patwardhan and Kapil Khambholja
 Chapter 2 
Evolutionary Biology and Drug Development
by Pierre M. Durand and Theresa L. Coetzer
 Chapter 3 
Novel Oncology Drug Development Strategies in the Era of Personalised Medicine
by C.R. Lemech, R.S. Kristeleit and H.T. Arkenau
 Chapter 4 
Drug Discovery into the 21st Century
by Klaus Pors
 Chapter 5 
Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development
by Sergio Y. Alcoser and Melinda G. Hollingshead
 Chapter 6 
Genetic Pharmacotherapy
by Celia Gellman, Susana Mingote, Yvonne Wang, Inna Gaisler-Salomon and Stephen Rayport
 Chapter 7 
Critical Human Hepatocyte-Based In Vitro Assays for the Evaluation of Adverse Drug Effects
by Albert P. Li
 Chapter 8 
The Use of In Vitro 3D Cell Models in Drug Development for Respiratory Diseases
by Song Huang, Ludovic Wiszniewski and Samuel Constant
 Chapter 9 
Chemical Biology: What is Its Role in Drug Discovery?
by Lisa Pirrie and Nicholas J. Westwood
 Chapter 10 
Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles
by Jolanta Natalia Latosińska and Magdalena Latosińska
 Chapter 11 
De-Risking Drug Discovery Programmes Early with ADMET
by Katya Tsaioun and Steven A. Kates
 Chapter 12 
Novel Approach to High Throughput Screening for Activators of Transcription Factors
by Natalya Smirnova, Dmitry Hushpulian, Rajiv Ratan and Irina Gazaryan
 Chapter 13 
Assessment of Cell Cycle Inhibitors by Flow Cytometry
by Paolo Cappella and Jürgen Moll
 Chapter 14 
Image-Based High-Content Screening in Drug Discovery
by Marjo Götte and Daniela Gabriel
 Chapter 15 
Recent Advances in Biotherapeutics Drug Discovery and Development
by Xiaotian Zhong, Peter Neumann, Michael Corbo and Evan Loh
 Chapter 16 
Drug Discovery by Aptamers in Protozoan Infectious Diseases
by Carsten Wrenger and Henning Ulrich
 Chapter 17 
Streamlining ICH Q6B Analytical Testing of Biotherapeutics
by Elizabeth Higgins, Elisabeth Kast and Amy Lachapelle
 Chapter 18 
Biomarkers in Drug Development: A Useful Tool but Discrepant Results May Have a Major Impact
by Abdel-Baset Halim
 Chapter 19 
Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development
by Sadhna Sharma and Amandeep Singh
 Chapter 20 
Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications
by Anitha Sironmani and Kiruba Daniel
 Chapter 21 
Mesenchymal Stem Cells as Vehicles for Targeted Therapies
by Gabriele Putz Todd, Michelle A LeRoux and Alla Danilkovitch-Miagkova

 
Drug Development - A Case Study Based Insight into Modern Strategies
Drug Development - A Case Study Based Insight into Modern Strategies
Editor Chris Rundfeldt

This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.

 

Chapter 1 
Discovery and Optimization of Inhibitors of DNA Methyltransferase as Novel Drugs for Cancer Therapy
by Jakyung Yoo and José L. Medina-Franco
 Chapter 2 
Development of Novel Secondary Hormonal Therapies for Castrate-Resistant Prostate Cancer
by Rahul Aggarwal and Charles J. Ryan
 Chapter 3 
Inhibitors of Proteinases as Potential Anti-Cancer Agents
by Karolina Gluza and Paweł Kafarski
 Chapter 4 
Histamine Receptors as Potential Therapeutic Targets for Cancer Drug Development
by Vanina A. Medina, Diego J. Martinel Lamas, Pablo G. Brenzoni, Noelia Massari, Eliana Carabajal and Elena S. Rivera
 Chapter 5 
Histone Deacetylase Inhibitors as Therapeutic Agents for Cancer Therapy: Drug Metabolism and Pharmacokinetic Properties
by Ethirajulu Kantharaj and Ramesh Jayaraman
 Chapter 6 
Antimicrobial Peptides: New Frontiers in the Therapy of Infections
by Mario Zucca, Sara Scutera and Dianella Savoia
 Chapter 7 
microRNAs as Therapeutic Targets to Combat Diverse Human Diseases
by Elizabeth Hong-Geller and Nan Li
 Chapter 8 
Potentiation of Available Antibiotics by Targeting Resistance – An Emerging Trend in Tuberculosis Drug Development
by Kerstin A. Wolff, Marissa Sherman and Liem Nguyen
 Chapter 9 
Antitubercular Drugs Development: Recent Advances in Selected Therapeutic Targets and Rational Drug Design
by Virgilio Bocanegra-García, Abraham García, Jose Prisco Palma-Nicolás, Isidro Palos and Gildardo Rivera
 Chapter 10 
Insight into the Key Structural Features of Potent Enoyl Acyl Carrier Protein Reductase Inhibitors Based on Computer Aided Molecular Design
by Auradee Punkvang, Pharit Kamsri, Kodchakon Kun-asa, Patchreenart Saparpakorn, Supa Hannongbua, Peter Wolschann and Pornpan Pungpo
 Chapter 11 
RNA Interference-Based Therapeutics: Harnessing the Powers of Nature
by Tamara Martinez, Natalia Wright, Covadonga Paneda, Ana I. Jimenez and Marta Lopez-Fraga
 Chapter 12 
P2X Receptors as New Therapeutic Targets
by Liang Xin, Xiao Yanjuan and Li Zhiyuan
 Chapter 13 
Pregnane X Receptor in Drug Development
by Su Sien Ong, Yue-Ming Wang, Sergio C. Chai and Taosheng Chen
 Chapter 14 
Crosstalk Between the Immune and Central Nervous Systems with Special Reference to Drug Development
by Takekazu Kubo, Shigeru Tokita and Toshihide Yamashita
 Chapter 15 
Liquiritigenin Attenuates Alzheimer’s-Like Neuropathology in an Amyloid Protein Precursor Transgenic Mouse Model and the Underlying Mechanisms
by Rui Ting Liu, Jin Tian Tang, Li Bo Zou, Jie Ying Fu and Qiu Jun Lu
 Chapter 16 
Novel Therapeutic Strategies for Chagas` Disease
by Alane Beatriz Vermelho, Carlos Alberto Manssour Fraga, Samir Aquino Carvalho, Edson Ferreira da Silva, Solange Lisboa de Castro, Igor de Almeida Rodrigues, Maria do Socorro dos Santos Rosa, Ana Claudia Fernandes Amaral and Giseli Capaci Rodrigues
 Chapter 17 
The Gut Microbiota as Target for Innovative Drug Development: Perspectives and a Case Study of Inflammatory Bowel Diseases
by Joan Vermeiren, Sam Possemiers, Massimo Marzorati and Tom Van de Wiele
 Chapter 18 
Endophytic Fungi of Tropical Forests: A Promising Source of Bioactive Prototype Molecules for the Treatment of Neglected Diseases
by Luiz H. Rosa, Mariana L.A. Vieira, Betania B. Cota, Susana Johann,Tânia M.A. Alves, Carlos L. Zani and Carlos A. Rosa
 Chapter 19 
Bioproduction of Depsidones for Pharmaceutical Purposes
by María Estrella Legaz, Roberto de Armas and Carlos Vicente
 Chapter 20 
Multi-Dose Container for Nasal and Ophthalmic Drugs: A Preservative Free Future?
by Degenhard Marx and Matthias Birkhoff
 Chapter 21 
Microneedle-Assisted Transdermal Delivery of Opioid Antagonists for the Treatment of Alcoholism
by Stan L. Banks, Audra L. Stinchcomb and Kalpana S. Paudel
 Chapter 22 
Innovative Proposals for Incentivizing Drug Development
by Kristina M. Lybecker
 Chapter 23 
Drug Experimentation in Healthy Volunteers
by Giovanni Gori, Giuseppe Pasqualetti, Catia Castiglioni, Corrado Blandizzi and Mario Del Tacca
 Chapter 24 
Changes in Research and Development of Medicinal Products since the Paediatric Regulation
by Adriana Ceci, Mariana Catapano, Cristina Manfredi, Ian Wong, Mine Orlu-Gul, Annarita Meneguz, Paola Baiardi, Oscar Della Pasqua, Achille Iolascon, Maurizio Scarpa and Antje Neubert
 

 

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