Pharma Tips

Therapeutic Management of Asthma

By: Pharma Tips | Views: 1645 | Date: 04-Jul-2011

BRONCHODILATORS DRUGSANTI LEUKOTRIENE DRUGSANTI INFLAMMATORY DRUGS

BRONCHODILATORS DRUGS:-

a) B2-adrenergic:

Examples:-
Salbutamol,Terbutaline,Ephedrine, Salmeterol,Formoterol,Bambuterol.

Mecanism of action:-
Dilate the bronchi by direct action on B2 adreno-receptors on smooth muscles. They relaxes bronchial muscles whatever spasmogen are involved. They also inhibit release of TNF-  release from monocytes, and increase mucus clearance by an action on cilia.

Unwanted effects:-
The commonest adverse effect of these drugs include: tremors; other side effects are tachycardia, cardiac dysrhythmia.

b) Methylxanthines:

Examples:-
Theophylline, Aminophyline,Choline theophyllinate.

Mecanism of action:-
1>Release of Ca+2 from sarcoplasmic reticulum, especially in skeletal and cardiac muscles.
2>Inhibition of phosphodiesterase enz.which degrades cyclic neucleotide intracellulary, so dilation occur.

Unwanted effects:-
The serious CVS effect is dysrhythmia; other effects are CNS & GIT disturbances.

c)Anticholinergics:

Examples:-
Atropine, Ipratropium bromide[Atrovent]

Mecanism of action:-
It causes bronchodilation by blocking cholinergic tone through blockadge of cholinergic receptor; act primarly in larger airways.

Unwanted effects:-
Dry mouth ,urinary retention ,hyperthermia  etc.

ANTI LEUKOTRIENE DRUGS:-

Examples:-
Montelukast, Zarfirlukast, Zileuton.(also inhibit LTB4 synthesis)

Mecanism of action:-
LT-C4 & LT-D4 are important mediators for bronchial asthma, these drugs competitively antagonize cys LT1 receptor mediated bronchoconstriction, increased vascular permeability  & recruitment of eosinophils.

Unwanted effects:-
Headache, skin rashes. Sometimes few cases of Churg-Strauss syndrome(vasculitis with eosinophilia)

ANTI INFLAMMATORY DRUGS

Corticosteroids:

Examples:-
Beclomethasone[Vanceril,Beclovent],Triamcinolone[Azmacort],Flunisolide[Aerobid],Fluticasone [Flovent] Dexamethasone

Mecanism of action:-
Corticosteroids penetrates into cells, bind to high affinity Cytoplasmic Receptor Protein (CRP) a structural change occur in steroid receptor complex that allow migration into nucleus & binding to Glucocorticoid Response Elements(GRE)-thereby inhibit transcription of  specific m-RNA, they are not bronchodilators.

Unwanted effects:-
Regular high dose can produces adrenal suppression in children .Other side effects are osteoporosis, susceptible to infection , palpitation of heart.

ANTI IgE DRUGS:-

Examples:-
Omalizumab.

Mecanism of action:-
Omalizumab is a recombinant humanized monoclonal antibody directed against IgE to inhibit the immune response to allergen exposure. This anti-IgE is directed against the binding site of IgE (Cepsilon3 domain) for the high-affinity receptor, and, as a result, prevents free-serum IgE from attaching to mast cells and other IgE receptor-expressing cells, preventing IgE-mediated responses.

Following allergen cross-linking of mast cell-bound IgE, these cells are activated and virtually immediately release a granule-associated substance, such as histamine. Within minutes, de novo synthesis of important lipid mediators (cysteinyl leukotrienes) is initiated from membrane phospholipids. Following a few hours, the activated mast cells are also capable of the transcription, translation, synthesis, and release of a large number of cytokines, including interleukin (IL)-4, IL-6, IL-9, IL-13, and tumor necrosis factor (TNF)-alpha.

Unwanted effects:-
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, tongue or throat); anxiety; cough; dizziness; fainting; fast or weak heartbeat; feeling unusually warm; flushing; hoarseness; new or worsening breathing problems, shortness of breath; numbness or tingling; symptoms of sinus or lung infection(congestion, cough, or fever); trouble swallowing; unusual lumps, growths, or moles; unusual swelling of the hands or feet; wheezing.
Previous Page Next Page

People Searching On This Page:
  • therapeutic management on asthma
  • ipratropium
  • therapeutic management for asthma
  • therapeutic treatment of asthma
  • therapeuticmanagement of asthma
  • therapeutic management of asthma
  • ige for asthma
  • asthma therapeutic management
  • omalizumab and release of cytokines from mast cells
  • salbutamol, terbutaline,ephedrine,salmetorol, and methylxanthimes
  • therapeutic management of asthma
  • therapeutic management of asthama
  • anti IgE OMALIZUMAB
  • clincal trials for omalizumab treating asthma
  • therapeutic management of asthma

Related Pages


Therapeutic Uses of Botulinum Toxin

Therapeutic Uses of Botulinum Toxin

Articles | Pharmacognosy | Herbal Drug
Date:
19-Jun-2011  Views: 1607

Therapeutic UsesBotulinum Toxin Use in DystoniaBotulinum Toxin Use in Spasticity ...
Executive production - Bulk drugs - Digvijaya Management Consultants

Executive production - Bulk drugs - Digvijaya Management Consultants

Jobs | Production | Mumbai
Date:
13-Jun-2011  Views: 2502

For a reputed client of Digvijaya - Exclusive recruitment consultants for Pharma/Biotech/CROs. ...
Lab Assistant - Vijaya Management services

Lab Assistant - Vijaya Management services

Jobs | Quality Control | Pune
Date:
09-Jun-2011  Views: 2501

company manufacture best in class laboratory instruments and consumables to perform a task with high level of precision and accuracy without any pain ...
Executive-Clinical Data Management

Executive-Clinical Data Management

Jobs | Clinical Research | Mumbai
Date:
01-Jun-2011  Views: 2181

ClinACE is a (CRO) with operations worldwide. We provide full service support for Phase II-IV, (PMS) for drugs, Medical Devices and 505(b) (2) submiss ...
Head - Clincal Data Management

Head - Clincal Data Management

Jobs | Medical Writer | Delhi
Date:
12-May-2011  Views: 1222

Tech Observer is a client-centric global Clinical Research Organization (CRO) providing innovative solutions and analytical support for all clinical r ...
Post Your Comments (No Login Require)
Name : (required)
Email : (required)
Website :

Comment : (required)

76  + 2 =     
Comments
People Searched About:
Therapeutic Management On Asthma   |   Ipratropium   |   Therapeutic Management For Asthma   |   Therapeutic Treatment Of Asthma   |   Therapeuticmanagement Of Asthma   |   Therapeutic Management Of Asthma   |   Ige For Asthma   |   Asthma Therapeutic Management   |   Omalizumab And Release Of Cytokines From Mast Cells   |   Salbutamol, Terbutaline,Ephedrine,Salmetorol, And Methylxanthimes   |   Anti Ige OMALIZUMAB   |   Therapeutic Management Of Asthma   |  
Google : 558 times | Yahoo : 19 times | Bing : 163 times |