Classification of Botulinum toxin

By: Pharma Tips | Views: 2963 | Date: 19-Jun-2011

Types, Target, Discover of Botulinum toxin.

Table-1. Types, Target, Discover of Botulinum toxin.

Type	Target	Discoverer	Year
A	SNAP-25	Landman	1904
B	VAMP	Ermengem	1897
C1	Syntaxin	Bengston and Seldon	1922
D	VAMP	Robinson	1929
E	SNAP-25	Gunnison	1936
F	VAMP	Moller and Scheibel	1960
G	VAMP	Gimenez and Ciccarelli	1970

•    BoNT-A and BoNT-E cleave synaptosome-associated protein (SNAP-25), a presynaptic membrane protein required for fusion of
      neurotransmitter-containing vesicles.

•    BoNT-B, BoNT-D, and BoNT-F cleave a vesicle-associated membrane protein (VAMP), also known as synaptobrevin.

•    BoNT-C acts by cleaving syntaxin, a target membrane protein.

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