Classification of Botulinum toxin

By: Pharma Tips | Views: 2806 | Date: 19-Jun-2011

Types, Target, Discover of Botulinum toxin.



Table-1. Types, Target, Discover of Botulinum toxin.


Type

Target

Discoverer

Year

A

SNAP-25

Landman

1904

B

VAMP

Ermengem

1897

C1

Syntaxin

Bengston and Seldon

1922

D

VAMP

Robinson

1929

E

SNAP-25

Gunnison

1936

F

VAMP

Moller and Scheibel

1960

G

VAMP

Gimenez and Ciccarelli

1970



•    BoNT-A and BoNT-E cleave synaptosome-associated protein (SNAP-25), a presynaptic membrane protein required for fusion of
      neurotransmitter-containing vesicles.

•    BoNT-B, BoNT-D, and BoNT-F cleave a vesicle-associated membrane protein (VAMP), also known as synaptobrevin.

•    BoNT-C acts by cleaving syntaxin, a target membrane protein.

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