Types, Target, Discover of Botulinum toxin.
Table-1. Types, Target, Discover of Botulinum toxin.
Type | Target | Discoverer | Year |
A | SNAP-25 | Landman | 1904 |
B | VAMP | Ermengem | 1897 |
C1 | Syntaxin | Bengston and Seldon | 1922 |
D | VAMP | Robinson | 1929 |
E | SNAP-25 | Gunnison | 1936 |
F | VAMP | Moller and Scheibel | 1960 |
G | VAMP | Gimenez and Ciccarelli | 1970 |
• BoNT-A and BoNT-E cleave synaptosome-associated protein (SNAP-25), a presynaptic membrane protein required for fusion of
neurotransmitter-containing vesicles.
• BoNT-B, BoNT-D, and BoNT-F cleave a vesicle-associated membrane protein (VAMP), also known as synaptobrevin.
• BoNT-C acts by cleaving syntaxin, a target membrane protein.