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Drug Dissolution Apparatus-I USP (Rotating Basket)

By: Mitul Shah | Views: 23784 | Date: 24-Mar-2011

The rotating basket apparatus (Apparatus 1) consists of a cylindrical basket held by a motor shaft. The basket holds the sample and rotates in a round flask containing the dissolution medium.

Drug Dissolution  Apparatus-I  USP (Rotating Basket)

The rotating basket apparatus (Apparatus 1) consists of a cylindrical basket held by a motor shaft. The basket holds the sample and rotates in a round flask containing the dissolution medium.

The entire flask is immersed in a constant-temperature bath set at 37°C. The rotating speed and the position of the basket must meet spe¬cific requirements set forth in the current USP.

The most common rotating speed for the basket method is 100 rpm. Dissolution calibration standards are available to make sure that these mechanical and operating requirements are met.

Calibration tablets containing prednisone are made especially for dissolution tests requiring disintegrating tablets, whereas salicylic acid.calibration tablets are used as a standard for non-disintegrating tablets.

Apparatus I is generally preferred for capsules and for dosage forms that tend to float or disintegrate slowly.

 

Figure  Apparatus I.
 Two basket attachment designs: On the left is the O-ring design and on the right is the three-pronged USP Apparatus 1 design.
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Comments
sudhakar  |  15-Jul-2012 19:08:29 IST
very nice information
stuart  |  07-Sep-2012 01:58:17 IST
it's awesome. thank you for nice presentation with figure.
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