Dissolution Apparatus and Detail As Per USP

By: Pharma Tips | Views: 52606 | Date: 24-Mar-2011

Tablets are grouped into uncoated. plain-coated, and enteric-coated tablets. The selection of a particular method for a drug is usually specified in the monograph for a particular drug product.

Dissolution Apparatus and Detail As Per USP


Dissolution Apparatus

              DISSOLUTION APPARATUS AND DETAIL AS PER USP.

APPARATUS

NAME

DRUG PRODUCT

Apparatus I

Rotating basket

Tablets

Apparatus II

Paddle

Tablets. capsules modified drug  products

Apparatus III

Reciprocating cylinder

Extended-release drug products.

Apparatus IV

Flow cell

Drug products containing low-water-soluble drug

Apparatus V

Paddle over disk

Transdermal drug products.

Apparatus VI

Cylinder

Transdermal drug products.

Apparatus VII

Reciprocating disk

Extended-release drug    products

Apparatus VIII

(Non-USP-NF)

Extended-release drug products (beads).

Apparatus IX

(Non-USP-NF)

Ointments, creams, transdermal drug products.

       

Tablets are grouped into uncoated. plain-coated,and enteric-coated tablets. The selection of a particular method for a drug isusually specified in the monograph for a particular drug product. Buccal andsublingual tablets are tested applying the uncoated tablet procedure. Tablelists various types of dissolution apparatus and the type of drug products that is often usedwith the apparatus. For Apparatus I and II, low rotational speeds affect the reproducibilityof the hydrodynamics; whereas at high rotational speeds. turbulence may occur.Dissolution profiles that show the drug dissolving too slowly or too rapidly may justify'increasing or decreasing the rotational speed (Gray et al, 2001).

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Comments
Karam Chand Pandey  |  13-May-2016 23:23:55 IST
Plz describe in detail about apparatus uses with reason
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