Tablets are grouped into uncoated. plain-coated, and enteric-coated tablets. The selection of a particular method for a drug is usually specified in the monograph for a particular drug product.
Dissolution Apparatus and Detail As Per USP
Dissolution Apparatus
| DISSOLUTION APPARATUS AND DETAIL AS PER USP. |
| APPARATUS | NAME | DRUG PRODUCT |
| Apparatus I | Rotating basket | Tablets |
| Apparatus II | Paddle | Tablets. capsules modified drug products |
| Apparatus III | Reciprocating cylinder | Extended-release drug products. |
| Apparatus IV | Flow cell | Drug products containing low-water-soluble drug |
| Apparatus V | Paddle over disk | Transdermal drug products. |
| Apparatus VI | Cylinder | Transdermal drug products. |
| Apparatus VII | Reciprocating disk | Extended-release drug products |
| Apparatus VIII | (Non-USP-NF) | Extended-release drug products (beads). |
| Apparatus IX | (Non-USP-NF) | Ointments, creams, transdermal drug products. |
Tablets are grouped into uncoated. plain-coated,and enteric-coated tablets. The selection of a particular method for a drug isusually specified in the monograph for a particular drug product. Buccal andsublingual tablets are tested applying the uncoated tablet procedure. Tablelists various types of dissolution apparatus and the type of drug products that is often usedwith the apparatus. For Apparatus I and II, low rotational speeds affect the reproducibilityof the hydrodynamics; whereas at high rotational speeds. turbulence may occur.Dissolution profiles that show the drug dissolving too slowly or too rapidly may justify'increasing or decreasing the rotational speed (Gray et al, 2001).