Applications of Floating Drug Delivery Systems

By: Pharma Tips | Views: 12453 | Date: 08-May-2011

Floating drug delivery offers several applications for drugs having poor bioavailability because of the narrow absorption window in the upper part of the gastrointestinal tract. It retains the dosage form at the site of absorption and thus enhances the bioavailability. These are summarized as follows.



          Floating drug delivery offers several applications for drugs having poor bioavailability because of the narrow absorption window in the upper part of the gastrointestinal tract. It retains the dosage form at the site of absorption and thus enhances the bioavailability. These are summarized as follows.

Sustained drug delivery:

              HBS systems can remain in the stomach for long periods and hence can release the drug over a prolonged period of time. The problem of short gastric residence time encountered with an oral CR formulation hence can be overcome with these systems. These systems have a bulk density of g1 as a result of which they can float on the gastric contents. These systems are relatively large in size and passing from the pyloric opening is prohibited. Recently sustained release floating capsules of nicardipine hydrochloride were developed and were evaluated in vivo. The formulation compared with commercially available micard capsules using rabbits. Plasma concentration time curves showed a longer duration for administration (16 hours) in the sustained release floating capsules as compared with conventional micard capsules (8 hours).

    Similarly a comparative study between the madopar HBS and madopar standard formulation was done and it was shown that the drug was released up to 8 hours in vitro in the former case and the release was essentially complete in less than 30 minutes in the latter case.

Site-specific drug delivery:
               These systems are particularly advantageous for drugs that are specifically absorbed from stomach or the proximal part of the small intestine, eg, riboflavin and furosemide. Furosemide is primarily absorbed from the stomach followed by the duodenum. It has been reported that a monolithic floating dosage form with prolonged gastric residence time was developed and the bioavailability was increased. AUC obtained with the floating tablets was approximately 1.8 times those of conventional furosemide tablets. A bilayer-floating capsule was developed for local delivery of misoprostol, which is a synthetic analog of prostaglandin e1 used as a protectant of gastric ulcers caused by administration of NSAIDs. By targeting slow delivery of misoprostol to the stomach, desired therapeutic levels could be achieved and drug waste could be reduced.

Absorption enhancement
              Drugs that have poor bioavailability because of site specific absorption from the upper part of the gastrointestinal tract are potential candidates to be formulated as floating drug delivery systems, thereby maximizing their absorption. A significant increase in the bioavailability of floating dosage forms (42.9%) could be achieved as compared with commercially available lasix tablets (33.4%) and enteric coated lasix-long product (29.5%).

Enlists examples of various drugs formulated as different forms of floting tablets.

Tablets    Chlorpheniraminemaleate
Theophylline
Furosemide
Ciprofolxacin
Pentoxyfillin
Captopril
Acetylsalicylicacid
Nimodipine
Amoxycillintrihydrate
VerapamilHCl
Isosorbidedinitrate
Sotalo
Atenolol
Isosorbidemononitrate
Acetaminophen
Ampicillin
Cinnarazine
Diltiazem
Florouracil
Piretanide
Prednisolone
Riboflavin- 5′ Phosphate


Previous Page Next Page

People Searching On This Page:
  • nmt4
  • Why floating tablets is used
  • application of floating
  • floating tablets use
  • developed floating drug list
  • application of floating tablets
  • why floating tablet use
  • floatin -20 tablets
  • floating tablet uses
  • application of floating on
  • applications of floatiing drug delivery system
  • applications of floating drug delivery system
  • floating tablet drug delivery system
  • applications of floating tablets
  • floating tablet drug candidate

Related Pages


Drug Delivery Systems Pharma Companies in World

Drug Delivery Systems Pharma Companies in World

Articles | Pharma Companies
Date:
14-Oct-2012  Views: 9999

US demand for drug delivery systems will grow 10 percent annually through 2012. Oral types will remain the largest drug delivery category while parent ...
Drugs Inspector Job Vacancy  in Drugs Control Department of KPSC

Drugs Inspector Job Vacancy in Drugs Control Department of KPSC

Jobs | Drug Inspector
Date:
05-Jul-2012  Views: 33062

Vacancy for Drugs Inspector in Drugs Control department of KPSC - Freshers may apply ...
Drug Inspector in A.P. Drugs Control Job Vacancy

Drug Inspector in A.P. Drugs Control Job Vacancy

Jobs | Drug Inspector
Date:
18-Feb-2012  Views: 22444

Recruitment applications are invited On-line through the proforma Application to be made available on WEBSITE (apspsc.gov.in) in from 22/02/2012 to 22 ...
Dendrimers -Novel Drug Delivery System

Dendrimers -Novel Drug Delivery System

Articles
Date:
18-Jun-2010  Views: 11139

Dendrimer is a highly branched polymer, as shown in the schematic below, and consists of a core where a monomer unit is attached. ...
Buccal Drug Delivery System

Buccal Drug Delivery System

Articles
Date:
18-Jun-2010  Views: 6459

Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. ...
Post Your Comments (No Login Require)
Name : (required)
Email : (required)
Website :

Comment : (required)

28  + 6 =     
Comments
People Searched About:
Nmt4   |   Why Floating Tablets Is Used   |   Application Of Floating   |   Floating Tablets Use   |   Developed Floating Drug List   |   Application Of Floating Tablets   |   Why Floating Tablet Use   |   Applications Of Floatiing Drug Delivery System   |   Applications Of Floating Drug Delivery System   |   Floating Tablet Drug Delivery System   |   Applications Of Floating Tablets   |   Floating Tablet Drug Candidate   |   Drug Candidate Floating Tablet   |   Facotr G1 Tablets   |   Floating Drug Delivery Systems   |   Flating Delivery Tablets   |   Floating Drug Delivery System   |  
Google : 1358 times | Yahoo : 22 times | Bing : 394 times |