Characterization of Nanosuspensions
By: Pharma Tips |
Views: 4430 |
Date: 02-Jun-2011
A critical parameter that defines the quality and physicochemical behavior ofnanosuspensions is the particle size distribution. The mean particle size and widthof distribution can be determined using photon correlation spectroscopy (PCS),laser diffraction (LD), and coulter counter techniques.
A critical parameter that defines the quality and physicochemical behavior of
nanosuspensions is the particle size distribution.
The mean particle size and width of distribution can be determined using photon correlation spectroscopy (PCS),
laser diffraction (LD), and coulter counter techniques.
The measuring range for PCS is 3 nm to 3 mm and LD can measure particles ranging from 0.05 to 80 mm
up to 2,000 mm.
The coulter counter gives an absolute number of particles per unit
volume for the different size classes.
The shape and surface morphology of nanosuspensions can be assessed by scanning electron microscopy and atomic force
microscopy.
The crystalline state of nanosuspensions can be characterized by differential
scanning calorimetry and X-ray diffraction.
Determination of zeta potential is important to assess the physical stability of nanosuspensions.
For nanosuspension formulations administered intravenously, additional parameters
such as surface hydrophilicity/hydrophobicity, sterility, and pyrogenicity need to
be determined.
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