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Methods of Emulsification

By: Pharma Tips | Views: 3295 | Date: 02-Jun-2011

In an emulsion preparation, the liquid that forms the dispersed phase and the liquidthat forms the continuous phase are influenced by the volume ratio of the liquids, thekind of emulsifying agent used, and its concentration in strong connection with thePIT.

In an emulsion preparation, the liquid that forms the dispersed phase and the liquid
that forms the continuous phase are influenced by the volume ratio of the liquids, the
kind of emulsifying agent used, and its concentration in strong connection with the
PIT. Emulsions may be prepared by high-pressure homogenizers, ultrasound homogenizers,
colloid mills, ball and roller mills, rotor/stator systems such as stirred vessels,
and electrical and condensation devices. The principle and operation of these various
equipments can be found in the literature (Walstra 1983; Becher 1977).

Membrane emulsification is a relatively new technique for producing emulsions
and has received increased attention over the past few years (Charcosset et al.
2004). In the membrane emulsification process, the dispersed phase is pressed
through the membrane pores to form droplets that are then carried away by a continuous
phase flowing across the membrane surface. The conventional direct membrane
emulsification process is shown schematically in Fig. 1.3.

Various other types of membrane emulsification processes and their applications
have been reviewed by Vladisavljevic and Williams (2005). Membrane emulsification
is a suitable technique for the production of single and multiple emulsions.
Compared with other emulsification processes, membrane emulsification processes
allow the production of emulsions at lower energy output. W/O/W emulsions of a
water soluble anticancer drug epirubicin prepared by membrane emulsification
have been used successfully for the treatment of liver cancer by hepatic arterial
injection chemotherapy (Higashi et al. 1995).
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